It happened Monday, Jan. 1 at around dawn in Queens on the northbound Cross Island Parkway, near Exit 36 and the Whitestone Bridge.
Authorities said the two-vehicle collision involved a Honda SUV and Mazda sedan, with all five victims in the Mazda.
Their identities have not yet been released.
The Mazda, which was traveling "at a high rate of speed" overturned after hitting a curb, ejecting three of the five, according to NBC New York.
The cause of the crash is under investigation.
This is a developing story. Check back to Daily Voice for updates.
Click here to follow Daily Voice Briarcliff and receive free news updates.